Learn more about personalized proactive genetic testing with Dr. Goranka Tanackovic, CEO of Gene Predictis & member of Clinique La Prairie scientific committee. Gene Predictis is a pioneering Swiss company specialized in precision medicine offering innovative diagnostic tools based on genetics that allow tailored treatments for patients. After joining Gene Predictis as CEO in 2011, she changed the vision and the strategy of the company to help it develop first in class diagnostic products answering important medical needs, win numerous awards and develop its business significantly.

A heart rhythm disorder

The ability of genetic screening to identify individuals with genetically determined heart rhythm disorders has been clearly demonstrated.
The most frequently diagnosed disease is congenital long QT syndrome (LQTS), with the three most frequently involved genes being KCNQ1, KCNH2, and SCN5A. LQTS is characterized by heart rate corrected QT interval prolongation at the EKG and potentially fatal arrhythmias, leading to syncope and sudden cardiac death.
Identification of variants in these genes warrants cardiological evaluation and follow-up, with possible prescription of beta-blockers. An important consequence in terms of prevention consists of recommendations concerning medication and notably the lists of drugs to avoided. Lifestyle recommendations vary according to the gene involved, consisting for example of limiting physical stress (e.g. risk of drowning; KCNQ1 gene) or auditory stress (e.g. alarm clock; KCNH2 gene).

Familial cancers

Our body is permanently exposed to stress (oxidative stress, UV irradiation, pollution, etc) and so is true for our cells and genomic DNA. These stresses induce DNA damage that has to be repaired to maintain genomic integrity. Diverse DNA repairing enzymes are involved in this process, among them BRCA1 and BRCA2 proteins, encoded by the BRCA1 and BRCA2 genes.

In addition to female breast and ovarian/fallopian tube cancers, BRCA1 and BRCA2 mutations have been implicated in other cancers, namely prostate, pancreatic, colorectal, gastric, biliary and melanoma cancers. In the case of positive family history of certain cancers these genes can be sequenced and eventual pathogenic mutations identified early.

Identification of mutations in this genes will result with a medical follow-up to allow early cancer detection or eventually, in the case of cancer, early surgical interventions improving the chances of cure. In addition preventive measures can be proposed to lower the risk of cancer development, such as: medication to lower the chance of developing breast and ovarian cancer (tamoxifen or aromatase inhibitors), breast self-exam training and education starting at young age for both women and men, yearly screening with breast magnetic resonance imaging (MRI) and mammogram, possibly starting at a younger age, clinical screening for ovarian cancer with transvaginal ultrasound and CA-125 blood tests done regularly, prostate cancer screening in men starting at age 45 (especially for men with a BRCA2 mutation) and regular cancer screening in both women and men for skin, colon and pancreas cancer.

The cast for the 57th Montreux Jazz edition included major figures of the current scene, pioneers of the sixties and seventies, monuments of blues and jazz, pop icons and legends in the making.

What is cellular senescence?

It’s a physiological process that plays a vital part in tissue development and regeneration. For instance, senescent cells help rebuild tissues and play a role in wound healing. Once their job is done, they destroy themselves and are eliminated by the immune system. As we age, these processes are perturbed, mainly as a result of chronic inflammation. This causes an increase in the number of senescent cells, which then exacerbate chronic inflammation. It’s a vicious circle. The changes involved are associated with pathologies such as high blood pressure, hyperlipidemia and hyperplasia, and over time, these gradually contribute to the development of so-called chronic diseases, which are the chief cause of illness and death in highly industrialized countries.

Clinique la prairie is a pioneer in this field. How does it apply this knowledge in practice?

Based on our knowledge, we have developed a longevity-oriented approach that works by activating the molecular mechanisms involved in tissue regeneration. This is complemented by medical, genetic and epigenetic profiling, nutrition, dietary supplements, stress management and advice on lifestyle (diet, exercise, sleep, etc.) to help slow the aging process.

All in all, longevity is primarily a matter of developing good habits.

Chronic overeating, nutritional deficiencies, lack of exercise or problems with sleep patterns can interfere with cell signalling pathways so that cells grow and divide too fast instead of withstanding stress in such a way as to help maintain and regenerate the metabolism.
Poor dietary and lifestyle choices can result in a higher proportion of senescent cells as we get older, and that can cause inflammation. Cellular imbalance is associated with chronic low-level age-related inflammation. It encourages the emergence of senescent cells and hinders their elimination by the immune system. Although senescent cells cannot divide, they secrete numerous pro-inflammatory factors that can contaminate nearby cells and transform them into senescent cells. This can lead to the development of chronic diseases that impair quality of life in old age.

Clinique La Prairie is proud to be the first partner to provide AudioVitality®’s innovative technology in sound therapy. This technology brings a paradigm shift in supporting well-aging, improving performance and in a range of preventative and curative approaches, including tinnitus.

AudioVitality® is a unique innovative technology that uses low frequency continuous sounds with optional harmonic distortions and binaural components in a sound-proofed environment in full immersion. The effects of RubesaSounds™ potentially imply physical, biological, neural, and mental systemic stimulations that affect health, wellbeing, performance and Well Aging. It stimulates the body's natural capacity to heal, and to regulate body vitality.

In the dedicated isolated studio, you lay comfortably down on your back on a massage bed. During the session that lasts 40 minutes, specifically-designed series of sounds (RubesaSounds™) are played, while your whole body is immersed in the sound environment, experiencing it throughout your body. All is controlled by an AudioVitality trained practitioner.

The AudioVitality® experience is based on 40 min sessions combining client anamnesis and possible problematic body zone identification.

In natural and urban environments, sounds are intermittent and vary with time. The brain considers sound as a signal with a variation and limit in time. The human brain is not generally used to dealing with continuous sounds. RubesaSounds™ are 3 minutes long continuous soundwaves that are highly structured with specific harmony and equilibrium or, on the contrary, with dissonance and tension. The constancy of the sound signal over time progressively reaches neural saturation. After several sounds have been played in a sequence, this mental saturation pushes the brain into an unexplored and unique pleasant experience of “letting go”.

The RubesaSounds™ continuous sounds innovation finds its inspiration in minimal 20th century music.

High frequency sounds are mainly perceived by the ear. Low frequency sounds are more complex. They are perceived simultaneously through multiple channels:

• Via the auditory pathway: cochlea, auditory cortex, like all audible sounds.
• Via whole-body perceptions, through specific skin mechanoreceptors: Pacini Corpuscles, Meissner Corpuscles, and Hair follicles (Møller and Pedersen, 2004).

Additionally, human hair and skin absorption of acoustic vibrations have been measured at higher frequencies between 1 and 6 kHz (Katz, 2000). Each part of the human body’s skin reacts to specific vibration frequencies (Diller, 2001). Each part of the body has a specific vibration receptor repartition. For example, inner and outer arms have different hair densities with subsequent hair follicles and Meissner corpuscle densities.

During AudioVitality® treatments, each sound is personalized with respect to the client’s characteristics and preferences. This way, the impact of sound is maximized for each body zone.

From this July, AudioVitality is integrated into the Master Detox program, and it can be added as an experience to any other program. Our practitioners will guide you through the Longevity Well Aging protocol.

Specific other protocols include Sports performance, using personalized RubesaSounds™ that stimulate specific body zones in relation to an athlete’s training and competition objectives. It aims to provide accelerated recuperation and subsequent improved sport performance, as well as to prevent injuries by its deep relaxing effect.

Building on the pioneering work in cellular therapy begun in 1931 by Dr Paul Niehans, visionary physician and researcher in cell revitalisation, Clinique La Prairie has never ceased to be involved in scientific research related to senescence and associated chronic diseases. Since 1990, Clinique La Prairie collaborates with an international, multidisciplinary team of renowned scientists in immunology, biochemistry, and other disciplines, to further study the approach developed by Dr Niehans.

Age-related changes in cytokine secretions plays a critical role in immunosenescence and subsequently, in the increase of age-related cellular senescence and associated chronic diseases.   

The scientific research sponsored by Clinique La Prairie has demonstrated that its original CLP Extract extract could improve age-related changes in cytokines secretions and to restore the immune profile. Age-related changes in cytokine secretions were reversed by using a transmitter gas, that at physiologic dose, functions as a cell signalling molecule among other beneficial effects. The specific study of the different immune cell populations showed that age-related alterations in both innate and adaptative immune cell populations were involved in immunosenescence. This successful period of investigation also showed that regardless the route of CLP Extract administration used, the results obtained were similar. This laid the foundation for the oral treatment given to patients-guests today during the complete and holistic Revitalisation program.

All these results underlined that immunosenescence is not an inescapable process, and that immune cells have an enormous plasticity that could be advantageously exploited to manage cellular senescence. Furthermore, immunosenescence appeared to be more a remodelling than a decline of the immune system.

These fundamental findings led to a patent entitled “Composition comprising Foetal Haemoglobin and Bacterial Endotoxin, and optionally Additional Foetal Liver Components” (International application No.: PCT/EP2004/00/001553).

Encouraged by these positive results, the aim of the following studies was to further investigate the beneficial effect that the original CLP Extract or some of its components could potentially have on chronic diseases such as colitis and osteoporosis, as well as in the prevention of allergy and transplant rejection. This work confirmed the observation that the actives of the original CLP Extract played a role in polarizing T-lymphocytes subsets towards a type that may have positive implication for susceptibility to allergic diseases in man.

In the applied study published in 2018, it was shown that the original CLP Extract could potentially be useful in maintaining bone structure through its anti-inflammatory action.

The formula originally created by Dr Niehans has evolved over the decades, always on the same scientific grounds and following the strictest medical safety standards. For several years now, the CLP Extract of Clinique La Prairie is a stabilized purified form that demonstrated the similar quality and benefits. It is administrated orally to patients to revitalise and regenerate cells in the week-long program called Revitalisation, in conjunction with bio-stimulants and, since 2021, new complementing formulas.

In fact, recent research has also focused on two areas. The first is a nutrigenomic strategy to detoxify cells by inducing a transcriptional factor with the ability to activate more than 3000 cytoprotective genes related to cellular detoxification and stimulation. This was delivered with a combination of 5 vegan nutraceuticals (“CLP cellular genomic REV FFS1-5 activator”) working on the immune system, the nervous system, a reduction in inflammation, gut microbiota health and sleep patterns.

The second area is the production of the “5-HMF” substance, known as a powerful antioxidant and cellular activator. Clinique La Prairie developed a natural process to produce it and integrate it into a drinkable organic plant complex (“HP-cellular active”).

Using an integrative scientific approach, all the results obtained over the last thirty years were reanalysed in the light of current knowledge in cellular senescence. This analysis has shown that the activating stem cell recruitment and differentiation as well as potential reversal of immunosenescence are mainly related to the activation of nutrient cell signalling pathways associated to health and longevity and the inhibition of those involved in chronic age-related inflammation.   

In the last 10 years, the longevity approach of Clinique La Prairie complements science with an expert holistic content. In that respect, in the Revitalisation program, the evolved Niehans science is integrated into a holistic plan of genetics, medicine, nutrition, wellbeing and movement, working together to help stimulate cell regeneration, fight the signs and causes of aging, and enhance overall mental and physical health.

The Revitalisation program is built with a focus on metabolism, inflammation, anti-aging and natural defenses, coming from an exclusive longevity approach used at Clinique La Prairie.
Discover more with Clinique La Prairie’s Medical Director, Dr. Heini

What are the benefits of the Revitalisation programme ?
 

The program contributes to rejuvenation by regenerating ageing cells and reinforce the body’s defence system.

Progressively, a greater vitality, improved mental performance, increased intellectual and physical endurance will appear, as well as a better sleep and an improved overall wellbeing.

How does Revitalisation help with the immune system?
 

While a healthy lifestyle is of course essential to help your immune system through a healthy lifestyle, medical supervision and immune-boosting program such as Revitalisation can provide a stronger approach to strengthen immunity on the long term.

We speak here about “trained innate immunity”, that is the ability of the immune system to develop increased resistance to reinfection and thus provide long-term protection against pathogenic reinfection. We can target it by epigenetic modifications and by stimulating an enhanced protective inflammatory response, that will induce the reprogramming of immune cells.

The Revitalisation program includes several stimuli and actives in its supplements and formulas that are known to support this induction of trained immunity, as well as cell regeneration.

Tell us more about the actives that induce trained immunity and stimulate cell regeneration?
 

The continued dedication to regenerative medicine means Clinique La Prairie is constantly spearheading new formulas to support wellbeing. The CLP Extract, first, remains central to the programme to help regenerate and fight the effects of aging.  Two activators have been added: a high-performance cellular active and a genomic-based cure.

The HP-Cellular Active is an organic plant complex taken daily during the stay. It features a potent substance that is known to improve oxygen supply to tissues, help regulate oxidative stress and stimulate cells’ protection.

The new CLP Cellular Genomic FFS1-5 is composed of five plant-based compounds that interact with the genes involved in cell stimulation and body’s systems modulations. Each compound is formulated with carefully selected micronutrients and plant extracts. They are first taken during the stay and continued at home for four weeks to continue the revitalizing protocol.

Of course, once at the clinic, clients must undergo a rigorous series of tests given by the medical team, with particulars they need to oversee the detailed treatments. These tests will include blood, electrocardiogram, ultra-sound and x-rays among others. Only then are the CLP Extract, bio-stimulants, immunotherapy and the cellular and genomic courses administrated.

To help you stay healthy and live longer, Clinique La Prairie’s programs aim at triggering balanced gene expressions with natural methods that act at the cellular level: ones that provides instructions for producing proteins associated with longevity rather than senescence.

In this approach, the nutrition guidance provided during the Revitalisation program plays a vital role. The expert nutritionist will target anti-inflammatory gut health and the guest’s specific needs to promote a healthy mindset for transformative habits.

Lowering stress is another essential component for positive epigenetics. That is why the programme integrates mind-to-body wellness therapies to help reduce stress such as regenerative light therapy, neuro-wave stimulation, workouts and revitalising massage. So guests enjoy deeper and more stable effects.
 

What will a person know from its Revitalisation’s DNA testing?
 

Many common medical conditions, such as cardiovascular disease, obesity, food intolerances and certain auto-immune diseases, are influenced by both genetic factors and lifestyle. An increased understanding of human genetics has brought about unprecedented medical progress. It is now possible to detect predispositions to develop many deficiencies and diseases and improve upon our inherited state of health through targeted interventions in long-term behaviour.

The predictive DNA test of Revitalisation is an advanced tool of personalized medicine: it offers a comprehensive overview of inherited risk factors and enables the tailoring of therapies and nutritional and lifestyle advice based on genetically predisposed factors.
 

Has the Revitalisation programme changed and evolved over the years?
 

Its essence and philosophy are the same. It was devised to increase energy levels, regenerate cells and boost the immune system, all of which helps combat the negative effects of ageing while having an overall fitness effect on the body and its organs. It is constantly monitored, researched and honed to be the most advanced regeneration and longevity programme.

As the Medical Director of Clinique La Prairie, how do you see the role of the doctor for the guest?
 

We value human connection and know that our guests do, too. This is why they will see their doctor several times throughout the weeklong program, building a sense of trust and comfort as they take them through the three medical objectives of any stay at the clinic: the testing, results and diagnosis at the beginning; the advice and therapies after that; and at the end of the stay, when guests leave feeling empowered by knowledge that gives them the tools for long-term results.

Longevity Hub by Clinique La Prairie in Bangkok is delighted to present you its wellness workshops

To reserve a space in our workshops in Bangkok, please click the link below, book though our Line channel or contact our Longevity Hub at +66 2207 7779.
The workshops are running at a participation charge of 1,000 Baht.

About our Longevity Hub in Bangkok

This first Clinique La Prairie flagship outside of Europe is a haven of rejuvenation and wellbeing that addresses beauty, longevity, nutrition and wellness concerns with scientifically proven treatments, lifestyle-enhancing products, and signature wellness traditions.

Located on level 15 of The St.Regis and extending over 1,500 sqm, the Bangkok center boasts 16 treatment rooms and medi-wellness facilities. The areas are spread across two levels with wet area facilities including rain showers, Thai herbal steam rooms, twilight rasul, vitality pools, foot reflexology water walk, and relaxation pods.

Discover More

Jump into spring with innovative recipe based on grapefruit, radish and vanilla

Plant-based cuisine and its incredible diversity of colors and flavors begins with sight and continues with taste for genuine sensory delight. Discover this vegan and gluten free recipe - Grapefruit Chutney with Radish & Vanilla

Ingredients

- 8 grapefruits
- 6 radishes
- 1 vanilla pod
- 1 shallot
- 1.5 tbsp olive oil
- 1.5tbsp white balsamic vinegar
- Espelette pepper
- White peper
- Salt

With his experience acquired in starred restaurants in Belgium and Luxembourg, and at the restaurants of two renowned Swiss institutes of luxury hospitality education (Ecole Hotelière in Lausanne, Glion in Montreux), Chef David Alessandria mixes his technical expertise and his passion for healthy cuisine which he believes is the future of gastronomy.

He was awarded in 2022 the prestigious title of MOF "Meilleur Ouvrier de France" or "Best craftsman in France".

Discover Clinique La Prairie's restaurant 

Clinique La Prairie And Mandarin Oriental London Partner To Launch Exclusive ‘Holistic Health’ Regeneration Experiences

We are glad to announce that we are partnering with Mandarin Oriental Hyde Park to offer unique Regeneration experiences designed with Holistic Health nutraceuticals to create a shift in the balance of an individual’s wellbeing. This is the first time we created signature experiences outside of our clinic and international hubs, and the first time our treatments will be available in the UK. Clinique La Prairie’s range of Holistic Health supplements – Age Defy, Purity, Balance and Energy – will also be available to be purchased at The Spa.